Invokana is more effective at reducing HbA1c and weight than some other oral T2DM treatments
Head-to head studies are not available for all drug combinations; network meta-analyses (NMA) allow indirect treatment comparisons to be made.
Methodology: In an independent NMA using a frequentist model, pairwise random-effects were performed to estimate study variance. The aim of this NMA, which reviewed 38 trials involving 23,997 patients, was to assess the comparative safety and efficacy of SGLT2is in treating hyperglycaemia in adults with T2DM. Data was not available for ertugliflozin at the time of analysis.
- Sahasrabudhe V, et al. J Clin Pharm. 2017;57(11):1432-1443
- Zaccardi F, et al. Diabetes Obes Metab. 2016;18(8):738-94