This website is intended for UK healthcare professionals only
Prescribing information can be found here
Invokana Early Intensification Icon

The importance of early identification

Why is it important to look for the early signs of diabetic kidney disease (DKD) in your patients with type 2 diabetes mellitus (T2DM)?

  • One of the earliest complications of T2DM is kidney decline 1
  • If recognised early kidney disease in diabetes can be effectively slowed down 2
  • Early screening and using medications with proven effectiveness can reduce the burden of DKD 2
  • 38% of patients with T2DM haven’t had a urine albumin check within the last year 3

Why ACR is a better early marker of diabetic kidney disease (DKD) in primary care than eGFR

tonneijck graph
  • A patients whole-kidney GFR may remain normal even in the presence of considerable loss of nephron mass. 4
  • The graph indicates that by the time the estimated glomerular filtration rate (eGFR) falls below 60 ml/min/1.73m2, the patient may have already lost 60-80% of their nephron mass.4

  • By using ACR testing, early signs of DKD can be detected before significant nephron loss has occurred.4

Using ACR and GFR categories to assess a patients risk

  • 38% of patients with T2DM haven’t had a urine albumin check within the last year 3
kdigo graph
eGFR testing alone does not give a true picture of a patient’s risk of worsening outcomes such as DKD progression and CV events. 4

Professor David Wheeler explains the importance of early detection of DKD in people with T2DM

References
  1. Afkarian M, et al. J Am Soc Nephrol 2013;24(2):302-308
  2. Reference 19
  3. Reference 18
  4. Tonneijck L, et al. J am Soc Nephrol 2017;28(4):1023-39
  5. Reference 20