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The importance of early identification

Why is it important to look for the early signs of diabetic kidney disease (DKD) in your patients with type 2 diabetes mellitus (T2DM)?

  • One of the earliest complications of T2DM is kidney decline 1
  • If recognised early kidney disease in diabetes can be effectively slowed down 2
  • Early screening and using medications with proven effectiveness can reduce the burden of DKD 2
  • 38% of patients with T2DM haven’t had a urine albumin check within the last year 3

Why ACR is a better early marker of diabetic kidney disease (DKD) in primary care than eGFR

tonneijck graph
  • A patients whole-kidney GFR may remain normal even in the presence of considerable loss of nephron mass. 4
  • The graph indicates that by the time the estimated glomerular filtration rate (eGFR) falls below 60 ml/min/1.73m2, the patient may have already lost 60-80% of their nephron mass.4

  • By using ACR testing, early signs of DKD can be detected before significant nephron loss has occurred.4

Using ACR and GFR categories to assess a patients risk

  • 38% of patients with T2DM haven’t had a urine albumin check within the last year 3
kdigo graph
eGFR testing alone does not give a true picture of a patient’s risk of worsening outcomes such as DKD progression and CV events. 4

Professor David Wheeler explains the importance of early detection of DKD in people with T2DM

  1. Afkarian M, et al. J Am Soc Nephrol 2013;24(2):302-308
  2. Reference 19
  3. Reference 18
  4. Tonneijck L, et al. J am Soc Nephrol 2017;28(4):1023-39
  5. Reference 20