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The importance of early identification

Why is it important to look for the early signs of diabetic kidney disease (DKD) in your patients with type 2 diabetes mellitus (T2DM)?

  • One of the earliest complications of T2DM is kidney decline 1
  • If recognised early kidney disease in diabetes can be effectively slowed down 2
  • Early screening and using medications with proven effectiveness can reduce the burden of diabetic kidney disease (DKD) 2
  • 1 in 3 T2DM patients haven’t had a urine albumin check within the last year 3

Why ACR is a better early marker of diabetic kidney disease (DKD) in primary care than eGFR

  • A patients whole-kidney GFR may remain normal even in the presence of considerable loss of nephron mass. 4
  • The graph indicates that by the time the estimated glomerular filtration rate (eGFR) falls below 60 ml/min/1.73m2, the patient may have already lost 60-80% of their nephron mass.4

  • By using ACR testing, early signs of DKD can be detected before significant nephron loss has occurred.4

Professor David Wheeler explains the importance of early detection of DKD in people with T2DM

  1. Afkarian M, et al. J Am Soc Nephrol 2013;24(2):302-308
  2. Diabetes with kidney disease: key facts. NHS Kidney Care March 2011
  3. National Diabetes Audit, 2017-18. Report 1: Care Processes and Treatment Targets, England and Wales, 13th June 2019
  4. Tonneijck L, et al. J am Soc Nephrol 2017;28(4):1023-39